A 3 months old baby visited the hospital with a history of pain and swelling in the left thigh. After evaluation, the baby has been diagnosed with Ewing's Sarcoma with pathological fracture. After discussion with team in Tumor Board we had advised a treatment of Neo adjuvant chemotherapy for 3 cycles and performed rotationplasty successfully at the age of 6 months. The patient is undergoing adjuvant chemotherapy post surgery and recovering well.